Miriam was born in Romania, and Immigrated to the british mandate of palastine in 1930. She served in Palmach, and continued her service in the Israel Defense Forces. She began working at the Knesset library during her studies of English literature and history.
In March 1964, Prime Minister Levi Eshkol asked Miriam to arrive at the Prime Minister's residence. They were married in a ceremony conducted by the Chief Rabbi of Jerusalem and returned to their daily work.
Prime Minister Benjamin Netanyahu and his wife Sara, expressed their deep sorrow over the passing of Miriam Eshkol, who had been a personal friend of theirs for many years. Miriam Eshkol had worked tirelessly toward the establishment of a visitor's center in memory of her late husband, former Prime Minister Levi Eshkol, which is due to open soon. "We regret that she will not be able to dedicate the center for which she had worked so hard," they said.
She will be buried alongside her husband on Mount Herzl.